Description
Product Characteristics:
Belonging to the glycosyltransferase 14 family, GCNT2 (glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)), also known as II, N-acetylglucosaminyltransferase, IGNT, CCAT, ULG3, GCNT5, GCNT2C or NACGT1, is a 400 amino acid glycosyltransferase that localizes to the Golgi apparatus. Other members of the glycosyltransferase 14 family include GCNT1, GCNT3, GCNT4, GCNT6 and GCNT7. A single-pass type II membrane protein, GCNT2 functions as a branching enzyme known as beta-1,6-N-acetylglucosaminyltransferase, which converts fetal i antigen to adult I antigen in erythrocytes during embryonic development. With expression levels increasing significantly during oncogenesis and development, GCNT2 is found at highest levels in adult prostate and fetal brain, and is found at low levels in heart, small intestine, colon, brain, pancreas and kidney.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: bA360O19.2, bA421M1.1, Beta 1 6 N acetylglucosaminyltransferase 2, CCAT, GCNT 2, GCNT2C, GCNT5, Glucosaminyl N acetyl transferase 2 I branching enzyme I blood group, Glucosaminyl N acetyl transferase 2 I branching enzyme, I beta 1 6 N acetylglucosaminyltransferase, I branching beta 1 6 acetylglucosaminyltransferase, I branching enzyme, IGNT, II, Ii blood group, MGC163396, N acetylglucosaminyltransferase, N acetyllactosaminide beta 1 6 N acetylglucosaminyltransferase, NACGT1, NAGCT1, ULG3.
Target Information: This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]